Table 1.

Passive immunization studies. See also Tables S1, S2, S6.

HIV-1 Env Epitope	Antibody	Challenge virus (route)	Antibody dose (mg/kg)	No. of animals (infected/total)	Reference
CD4 binding site	b12	SHIVSF162P4 (vaginal)	25	0/4	(Parren et al., 2001)
			5	2/4
			1	4/4
		SHIVSF162P3 (vaginal)	25	1/9	(Hessell et al., 2007)
	VRC01	SHIVSF162P3 (vaginal)	20	0/4	(Ko et al., 2014)
		SHIVSF162P3 (rectal)	20	0/4	(Ko et al., 2014)
		SHIVSF162P3 (oral)	20	0/4	(Hessell et al., 2009a)
			5	1/5
		SHIVBaL.P4 (rectal)	20	0/6	(Ko et al., 2014)
			5	0/6	(Ko et al., 2014)
			1.25	0/4	Unpublished
			0.3	16/22	(Ko et al., 2014)
		SHIVAD8EO (rectal)	50	1/2	(Shingai et al., 2014)
			20	2/2
	VRC01LS	SHIVSF162P3 (rectal)	20	1/6	Unpublished
		SHIVBaL.P4 (rectal)	0.3	5/12	(Ko et al., 2014)
		SHIVBG505 (rectal)	20	0/4	Unpublished
	VRC07–523LS	SHIVBaL.P4 (rectal)	0.2	1/4	(Rudicell et al., 2014)
			0.05	4/4
		SHIVSF162P3 (rectal)	20	0/6	Unpublished
	N6LS	SHIVBG505 (rectal)	20	0/4	Unpublished
			10	1/4
			2.5	2/4
	3BNC117	SHIVAD8EO (rectal)	5	0/2	(Shingai et al., 2014)
			1	2/2
		SHIV327c (rectal)	10	3/4	(Julg et al., 2017)
			2	3/3
V1V2	PGDM1400	SHIV325C (rectal)	2	0/5	(Julg et al., 2017)
			0.4	0/5
			0.08	3/4
	CAP256.VRC26.25LS	SHIV325C (rectal)	2	0/4	(Julg et al., 2017)
			0.4	0/4
			0.08	0/4
	PG9	SHIVBaL.P4 (rectal)	20	2/6	(Ko et al., 2014)
			5	3/6
			0.3	6/6
V3-glycan	PGT121	SHIVSF162P3 (vaginal)	5	0/5	(Moldt et al., 2012)
			1	0/5
			0.2	2/5
		SHIVAD8EO (rectal)	20	0/2	(Shingai et al., 2014)
			5	1/2
			1	0/2
			0.2	2/2
		SHIV327c (rectal)	10	0/4	(Julg et al., 2017)
			2	1/3
	PGT126	SHIVSF162P3 (vaginal)	10	0/5	(Moldt et al., 2016)
			2	3/5
			0.4	4/5
		SHIVSF162P3 (rectal)	10	1/4	(Moldt et al., 2016)
			2	2/4
			0.4	4/4
	10–1074	SHIVAD8EO (rectal)	20	0/2	(Shingai et al., 2014)
			5	0/2
			1	2/2
High mannose glycan	2G12	SHIVSF162P3 (vaginal)	40	2/5	(Hessell et al., 2009b)
MPER	4E10	SHIVBa-L (rectal)	50	0/6	(Hessell et al., 2010)
	2F5	SHIVBa-L (rectal)	50	0/6	(Hessell et al., 2010)
	10E8	SHIVBaL.P4 (rectal)	20	0/6	(Ko et al., 2014)
			5	0/6
			0.3	3/6