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. 2019 Jul 22;98(11):1186–1194. doi: 10.1177/0022034519864592

Figure 4.

Figure 4.

Sox10 is required for secretory cell fate. (A, B) Genetic ablation of Sox10 in epithelial cells leads to loss of Kit+ progenitors (arrow) in embryonic day 16 endbuds. Loss of Sox10 also led to a decrease in proliferation (CCND1) in the epithelium (CDH1). (C, D) Comparing control glands with Sox10fl/fl shows loss of differentiating acinar cells (identified by expression of SMGc and AQP5). AQP5, aquaporin 5; CCND1, cyclin D1; CDH1, cadherin 1; KIT, KIT proto-oncogene receptor tyrosine kinase; SMGc, submandibular gland protein C. Scale bar: 20 µm. From Figure 4 of Athwal et al. (2019).