Figure 5.

Lineage tracing in adult glands. Duct, myoepithelial, and acinar cells are mainly maintained by separate lineages. ¹Sox2 lineage tracing in adult mice is specific to sublingual gland. ²A modest number of duct cells were lineage traced from Acta2+ cells in this study. ³A modest number of acinar cells were lineage traced from Trp63 following long-term chase in the submandibular gland (SMG). ⁴In parotid gland (PG) specifically, Dcpp+ intercalated ducts (IDs) infrequently also give rise to acinar cells. Dcpp, demilune cell and parotid protein 1; GCT, granular convoluted tubules; P, postnatal day. Dotted arrows indicate age-specific or rare events reported.