Figure 1.

Partial least squares–discriminant analysis of top 15 known metabolites differently expressed among the different study groups at baseline. Typically, a VIP of 2 or greater is highly significant. Red indicates high expression and green indicates low expression. CA-PD, plaque from dentin carious lesions of caries-active subjects; CA-PE, plaque from enamel lesion of caries-active subjects; CA-PF, plaque from carious-lesion free tooth surfaces of caries-active subjects; CF-PF, plaque from carious-lesion free tooth surfaces of caries-free subjects.