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. 2019 Jul 31;294(38):14149–14162. doi: 10.1074/jbc.RA118.005263

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© 2019 Ke et al.

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Figure 6. — Co-aggregation of 14-3-3 proteins with phosphorylated tau in neurons in aged TAU58/2 mice. A, staining of young and old TAU58/2 and nontransgenic (nontg) control brains with antibodies to 14-3-3σ (red) and phosphorylated tau (pS214; green). Open arrowheads indicated neurons with lack of neuronal 14-3-3σ staining. Arrows indicated focal staining of 14-3-3σ aggregates. Inset, magnification of neurons in aged nontransgenic staining. Scale bar, 50 μm. B, staining of young and old TAU58/2 and nontransgenic (nontg) control brains with antibodies to 14-3-3β (red) and phosphorylated tau (pS214; green). Arrowheads indicate cytoplasmic accumulation of 14-3-3β. Arrows indicated focal staining of 14-3-3β aggregates. Scale bar, 50 μm.