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HDX-MS of KRASV14I shows exposure of regions surrounding nucleotide. A, deuterium incorporation into four peptides that demonstrate the altered exchange kinetics in KRASV14I, KRASWT, and KRASA146T. The full HDX-MS dataset can be found in Fig. 4 and Table S1. B, regions of KRASV14I (highlighted in red) demonstrate increased deuterium exchange relative to KRASWT.
