Table 1.
Amino acids concentrations in the sera of mice exposed to eight daily injections of either ASNase or PBS excipient
Data were analyzed by two-factor ANOVA with ASNase and age as independent factors. Main effects of ASNase and age are shown in columns to the right of the treatment groups. Means in a row not sharing a common letter are different, reflecting an ASNase × age interaction (*, p < 0.05).
| Amino acids in serum | Average values (μm) |
p values |
||||
|---|---|---|---|---|---|---|
| Juv PBS (n = 9) | Juv ASNase (n = 9) | Adult PBS (n = 6) | Adult ASNase (n = 8) | Effect of ASNase | Effect of age | |
| Alanine | 357 ± 29 | 511 ± 56 | 348 ± 24 | 451 ± 104 | 0.002* | 0.351 |
| Arginine | 138 ± 9 | 173 ± 22 | 96 ± 21 | 107 ± 26 | 0.047* | 0.000* |
| Asparagine | 42.4 ± 31.3 | 5.7 ± 0.4 | 40.1 ± 33.1 | 5.6 ± 0.6 | 0.004* | 0.915 |
| Aspartate | 40 ± 24 | 21 ± 11 | 36 ± 21 | 20 ± 9 | 0.042* | 0.746 |
| Cystine | 6.3 ± 3.2 | 3.4 ± 0.3 | 3.5 ± 3.7 | 4.0 ± 6.8 | 0.628 | 0.655 |
| Glutamate | 81 ± 6 (b) | 168 ± 74 (b) | 57 ± 38 (b) | 330 ± 77 (a) | 0.000* | 0.034* |
| Glutamine | 405 ± 16 | 242 ± 49 | 597 ± 159 | 263 ± 120 | 0.001* | 0.090 |
| Glycine | 783 ± 47 (c) | 1151 ± 129 (a) | 449 ± 61 (b) | 512 ± 53 (b) | 0.000* | 0.000* |
| Histidine | 60 ± 3 | 62 ± 6 | 59 ± 10 | 56 ± 14 | 0.879 | 0.581 |
| Isoleucine | 54 ± 4 | 68 ± 10 | 69 ± 21 | 75 ± 18 | 0.246 | 0.208 |
| Leucine | 69 ± 4 | 93 ± 21 | 112 ± 36 | 120 ± 30 | 0.269 | 0.027* |
| Lysine | 289 ± 54 | 449 ± 95 | 188 ± 38 | 237 ± 64 | 0.003* | 0.000* |
| Methionine | 65 ± 6 | 74 ± 10 | 74 ± 21 | 76 ± 26 | 0.612 | 0.594 |
| Proline | 304 ± 12 | 312 ± 23 | 304 ± 168 | 285 ± 62 | 0.918 | 0.791 |
| Serine | 241 ± 11 | 344 ± 51 | 124 ± 17 | 178 ± 43 | 0.000* | 0.000* |
| Threonine | 203 ± 11 | 288 ± 26 | 156 ± 25 | 244 ± 81 | 0.007* | 0.117 |
| Tryptophan | 87 ± 5 | 76 ± 2 | 109 ± 23 | 106 ± 20 | 0.455 | 0.012* |
| Valine | 168 ± 21 | 225 ± 33 | 205 ± 58 | 235 ± 59 | 0.109 | 0.380 |