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. 2019 Jul 26;294(38):13915–13927. doi: 10.1074/jbc.RA119.009737

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© 2019 Wang et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 8. — The proposed model of the dynamic binding between RPA and ssDNA. A, RPA undergoes rapid association and dissociation with dT₁₀ using the 10-nt-binding mode. B, RPA switches dynamically between the 10- and 20-nt-binding modes on a 20-nt ssDNA. With increasing protein concentrations, two RPAs may contact the DNA side-by-side in the 10 + 10–nt mode. C, RPA switches dynamically between the 20- and 30-nt-binding modes on a 30-nt ssDNA. With increasing protein concentrations, two or three RPAs may contact the DNA in the 20 + 10–nt mode and the 10 + 10 + 10–nt mode. D, RPA switches dynamically between the 20- and 30-nt-binding modes on a 60-nt ssDNA and quickly diffuses on the ssDNA. With increasing protein concentrations, two to six RPAs may contact the DNA in the 30 + 30–nt mode, the 20 + 20 + 20–nt mode, the 20 + 20 + 10 + 10–nt mode, the 20 + 10 + 10 + 10 + 10–nt mode, and the 10 + 10 + 10 + 10 + 10 + 10–nt mode.