Table 1.
Characteristics of All Outcome Data Sets
| Outcome | Consortium | Definition | Total Population | Ethnicity | Cases (%) | Controls | References |
|---|---|---|---|---|---|---|---|
| Cognitive performance | UK Biobank and COGENT | Cognitive performance was assessed using a test of verbal‐numerical reasoning in UK Biobank and various neuropsychological tests in COGENT study | 257 841 | European | ··· | ··· | Lee et al (2018)20 |
| Alzheimer disease | IGAP(Stage 1) | WHO definition; the most common form of dementia. Dementia is a syndrome in which there is deterioration in memory, thinking, behavior and the ability to perform everyday activities | 54 162 | European | 17 008 (31.4%) | 37 154 | Lambert et al (2013)23 |
| Coronary heart disease | CARDIoGRAMplusC4D | Coronary stenosis >30%, documented angina, documented myocardial infarction | 184 305 | 77% European | 60 801 (33.0%) | 23 504 | Nikpay et al (2015)24 |
| Myocardial infarction | CARDIoGRAMplusC4D | Documented myocardial infarction; myocardial cell necrosis attributable to major and constant ischemia | 54 162 | 77% European | 42 560 (78.6%) | 11 602 | Nikpay et al (2015)24 |
| Systolic blood pressure | UK Biobank | Electronically measured systolic blood pressure at baseline visit | 473 891 | White British | ··· | ··· | UK Biobank (Neale's lab) (2018)25 |
| Ischemic stroke—any type | MEGASTROKE | WHO definition; rapidly developing clinical signs of focal (or global) disturbance of cerebral function, with symptoms lasting ≥24 h or leading to death, with no apparent cause other than of vascular origin of a neurological deficit persisting >24 h related to a vascular insult to the brain | 514 791 | Mixed | 60 341 (11.7%) | 454 450 | Malik et al (2018)26 |
| Ischemic stroke—cardioembolic stroke | MEGASTROKE | A type of ischemic stroke attributable to emboli coming from heart | 514 791 | Mixed | 9006 (1.7%) | 505 785 | Malik et al (2018)26 |
| Ischemic stroke—large‐artery atherosclerotic stroke | MEGASTROKE | A type of ischemic stroke attributable to atherosclerosis of major intracranial arteries | 514 791 | Mixed | 6688 (1.3%) | 508 103 | Malik et al (2018)26 |
| Ischemic stroke—small‐vessel disease stroke | MEGASTROKE | A type of ischemic stroke attributable to pathological processes of small arteries, arterioles, venules, and capillaries of the brain | 514 791 | Mixed | 11 710 (2.3%) | 503 081 | Malik et al (2018)26 |
COGENT indicates Cognition Genomics Consortium; IGAP, International Genomics of Alzheimer Project; WHO, World Health Organization.