Table 3.
Results From All MR Analyses for the Association of Uric Acid With Coronary Heart Disease, Myocardial Infarction, and Systolic Blood Pressure
| Uric Acid on CHD | OR (95% CI) | P Value |
|---|---|---|
| Analysis with 28 SNPs | ||
| Fixed‐effects IVW | 1.08 (1.02–1.14) | 0.01 |
| Weighted median | 1.05 (0.99–1.11) | 0.10 |
| MR‐Egger | 1.02 (0.94–1.12) | 0.63 |
| MR‐PRESSO (outlier corrected; 1 outlier) | 1.07 (1.03–1.12) | 2.99×10−03 |
| MR‐PRESSO (raw) | 1.08 (1.02–1.16) | 0.02 |
| MVMR adjusting for BMI | 1.07 (1.01–1.14) | 0.04 |
| Analysis with 7 SNPsa | ||
| Fixed‐effects IVW | 1.04 (0.97–1.11) | 0.29 |
| Weighted median | 1.03 (0.97–1.09) | 0.29 |
| MR‐Egger | 1.03 (0.95–1.11) | 0.58 |
| MR‐PRESSO (raw; 0 outliers) | 1.04 (0.97–1.11) | 0.29 |
| Uric Acid on MI | OR (95% CI) | P Value |
|---|---|---|
| Analysis with 28 SNPs | ||
| Fixed‐effects IVW | 1.09 (1.02–1.16) | 0.02 |
| Weighted median | 1.06 (0.99–1.12) | 0.08 |
| MR‐Egger | 1.01 (0.92–1.12) | 0.80 |
| MR‐PRESSO (outlier corrected; 1 outlier) | 1.08 (1.03–1.14) | 4.41×10−03 |
| MR‐PRESSO (raw) | 1.10 (1.01–1.18) | 0.03 |
| MVMR adjusting for BMI | 1.08 (1.00–1.17) | 0.05 |
| Analysis with 7 SNPsa | ||
| Fixed‐effects IVW | 1.04 (0.97–1.12) | 0.28 |
| Weighted median | 1.04 (0.98–1.11) | 0.22 |
| MR‐Egger | 1.03 (0.93–1.14) | 0.54 |
| MR‐PRESSO (raw; 0 outliers) | 1.04 (0.97–1.12) | 0.28 |
| Uric Acid on SBP | β (95% CI) | P Value |
|---|---|---|
| Analysis with 28 SNPs | ||
| Fixed‐effects IVW | 0.47 (−0.02 to 0.95) | 0.07 |
| Weighted median | 0.23 (−0.07 to 0.53) | 0.13 |
| MR‐Egger | −0.25 (−0.97 to 0.47) | 0.49 |
| MR‐PRESSO (outlier corrected; 4 outliers) | 0.58 (0.19–0.97) | 0.01 |
| MR‐PRESSO (raw) | 0.57 (−0.02 to 1.16) | 0.07 |
| MVMR adjusting for BMI | 0.56 (−0.05 to 1.17) | 0.08 |
| Analysis with 7 SNPsa | ||
| Fixed‐effects IVW | 0.34 (−0.18 to 0.86) | 0.25 |
| Weighted median | 0.21 (−0.09 to 0.51) | 0.15 |
| MR‐Egger | −0.12 (−0.53 to 0.30) | 0.59 |
| MR‐PRESSO (outliers corrected; 1 outlier) | 0.31 (−0.19 to 0.80) | 0.28 |
| MR‐PRESSO (raw) | 0.36 (−0.19 to 0.90) | 0.25 |
BMI indicates body mass index; CHD, coronary heart disease; IVW, inverse variance weighted; MR‐PRESSO, Mendelian Randomization Pleiotropy Residual Sum and Outlier; MI, myocardial infarction; MR, Mendelian randomization; MVMR, multivariable Mendelian randomization analysis; SBP, systolic blood pressure.
a
The 7 non‐pleiotropic SNPs that are associated with only uric acid or/and gout.