Table 4.
Results From All MR Analyses for the Association of Uric Acid With Ischemic Stroke and its Subtypes
| Uric Acid on Ischemic Stroke | OR (95% CI) | P Value |
|---|---|---|
| Analysis with 28 SNPs | ||
| Fixed‐effects IVW | 1.00 (0.94–1.06) | 0.99 |
| Weighted median | 0.98 (0.93–1.03) | 0.42 |
| MR‐Egger | 0.95 (0.85–1.05) | 0.31 |
| MR‐PRESSO (outlier corrected; 1 outlier) | 1.00 (0.95–1.05) | 0.87 |
| MR‐PRESSO (raw) | 1.00 (0.94–1.08) | 0.86 |
| MVMR adjusting for BMI | 0.99 (0.92–1.07) | 0.89 |
| Analysis with 7 SNPsa | ||
| Fixed‐effects IVW | 0.96 (0.91–1.02) | 0.20 |
| Weighted median | 0.97 (0.92–1.03) | 0.33 |
| MR‐Egger | 0.99 (0.93–1.06) | 0.82 |
| MR‐PRESSO (raw; 0 outliers) | 0.96 (0.91–1.02) | 0.20 |
| Uric Acid on CES | OR (95% CI) | P Value |
|---|---|---|
| Analysis with 28 SNP | ||
| Fixed‐effects IVW | 0.97 (0.89–1.05) | 0.44 |
| Weighted median | 0.95 (0.86–1.05) | 0.32 |
| MR‐Egger | 0.92 (0.82–1.04) | 0.20 |
| MR‐PRESSO (raw; 0 outliers) | 0.97 (0.89–1.06) | 0.49 |
| MVMR adjusting for BMI | 0.97 (0.89–1.06) | 0.50 |
| Analysis with 7 SNPsa | ||
| Fixed‐effects IVW | 0.93 (0.87–1.00) | 0.08 |
| Weighted median | 0.95 (0.85–1.06) | 0.33 |
| MR‐Egger | 0.97 (0.85–1.10) | 0.60 |
| MR‐PRESSO (raw; 0 outliers) | 0.93 (0.87–1.00) | 0.08 |
| LAS | OR (95% CI) | P Value |
|---|---|---|
| Analysis with 28 SNPs | ||
| Fixed‐effects IVW | 1.01 (0.88–1.15) | 0.94 |
| Weighted median | 0.94 (0.83–1.07) | 0.36 |
| MR‐Egger | 0.89 (0.74–1.08) | 0.24 |
| MR‐PRESSO (outliers corrected; 1 outlier) | 1.00 (0.88–1.13) | 0.98 |
| MR‐PRESSO (raw) | 1.01 (0.88–1.16) | 0.87 |
| MVMR adjusting for BMI | 1.00 (0.86–1.15) | 0.98 |
| Analysis with 7 SNPsa | ||
| Fixed‐effects IVW | 0.92 (0.84–1.01) | 0.13 |
| Weighted median | 0.93 (0.81–1.06) | 0.27 |
| MR‐Egger | 0.93 (0.79–1.10) | 0.41 |
| MR‐PRESSO (raw; 0 outliers) | 0.92 (0.84–1.01) | 0.13 |
| SVS | OR (95% CI) | P Value |
|---|---|---|
| Analysis with 28 SNPs | ||
| Fixed‐effects IVW | 1.04 (0.92–1.16) | 0.55 |
| Weighted median | 1.05 (0.94–1.17) | 0.41 |
| MR‐Egger | 1.08 (0.90–1.28) | 0.42 |
| MR‐PRESSO (outliers corrected; 1 outlier) | 1.03 (0.93–1.13) | 0.62 |
| MR‐PRESSO (raw) | 1.04 (0.92–1.17) | 0.54 |
| MVMR adjusting for BMI | 1.02 (0.90–1.15) | 0.79 |
| Analysis with 7 SNPsa | ||
| Fixed‐effects IVW | 1.02 (0.93–1.12) | 0.71 |
| Weighted median | 1.04 (0.92–1.17) | 0.56 |
| MR‐Egger | 1.09 (0.94–1.26) | 0.27 |
| MR‐PRESSO (raw; 0 outliers) | 1.02 (0.93–1.12) | 0.72 |
BMI indicates body mass index; CES, cardioembolic stroke; IVW, inverse variance weighted; LAS, large‐artery atherosclerotic stroke; MR, Mendelian randomization; MR‐PRESSO, Mendelian Randomization Pleiotropy Residual Sum and Outlier; MVMR, multivariable Mendelian randomization analysis; SVS, small‐vessel stroke.
a
The 7 non‐pleiotropic SNPs that are associated with only uric acid or/and gout.