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. 2019 Aug 23;8(17):e011468. doi: 10.1161/JAHA.118.011468

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Time course changes in NT‐proBNP (N‐terminal pro‐B‐type or brain natriuretic peptide)/estimated mature BNP (emBNP) ratio and cGMP during hospitalization of patients with acute decompensated heart failure (ADHF). A, Time course of NT‐proBNP/emBNP ratios in patients with ADHF and with (red) and without (blue) worsening renal function (WRF). *P<0.05 vs the patients without WRF at the corresponding times, ^# P<0.05 vs the overall time course in those without WRF (1‐way repeated ANOVA). B, Time course changes in plasma cGMP in patients with above‐median NT‐proBNP/emBNP ratio (red) and with below‐median NT‐proBNP/emBNP ratio (blue). One‐way repeated ANOVA through protocol: no statistical significance. BD indicates before discharge. *P<0.05 vs the patients without WRF at each time point. AD; admission.