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. 2019 Aug 31;8(17):e012809. doi: 10.1161/JAHA.119.012809

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A, Principal components analysis of metabolites from tissues after cardiac arrest and resuscitation. B, Loading plot of metabolites. All 4 organs have distinct metabolic profiles after cardiac arrest and after resuscitation, with the brain being the one organ that exhibited drastic alterations only after resuscitation. We superimposed the controls of all 4 organs into 1 point. As such, the “control” serves as a control for all 4 organs. B indicates brain; CA, cardiac arrest; CON, control; CPB, cardiopulmonary bypass; H, heart; K, kidney; L, liver.