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. Author manuscript; available in PMC: 2020 Sep 12.
Published in final edited form as: J Med Chem. 2019 Aug 16;62(17):8249–8273. doi: 10.1021/acs.jmedchem.9b01004

Figure 1.

Figure 1.

(A) Analysis of the synthesis of glucosylceramide (GlcCer) in C. neoformans or J774 cells labelled with [3H] palmitate and treated with 1 at the indicated concentrations; (B) Survival studies of mice infected intranasally with 5 × 105 C. neoformans cells and treated via i.p. injection on the day of infection with 1.2 mg/kg/day of fluconazole (Flu), 1 or 2. *Compound 2 versus no drug, P value of 0.0018; (C) Structures of 1 (BHBM) and 2 (D13).