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. Author manuscript; available in PMC: 2020 Sep 12.
Published in final edited form as: J Med Chem. 2019 Aug 16;62(17):8249–8273. doi: 10.1021/acs.jmedchem.9b01004

Figure 3.

Figure 3.

In vitro time-kill activities of (A) 5.2d, (B) 5.2e, (C) 5.6a, (D) 5.8 and (E) 5.8a. Time-kill activity was determined using an in vitro time-kill kinetics assay in which the compounds were co-incubated with C. neoformans cells at 37°C, 5% CO2, pH 7.4. The number of CFU is counted during 96 h of incubation. All of the compounds displayed antifungal activity in a dose-dependent manner.