. Author manuscript; available in PMC: 2020 Sep 12.

Published in final edited form as: J Med Chem. 2019 Aug 16;62(17):8249–8273. doi: 10.1021/acs.jmedchem.9b01004

Table 9.

FICI values of 5.2d combined with clinical drugs against 7 fungal strains

Fungal strain	5.2d/Flu^*	5.2d/Vori^*	5.2d/Itra^*	5.2d/Caspo^*	5.2d/AB^*
C. neoformans	0.065	0.072	0.072	ND	0.086
C. albicans	0.625	0.256	0.128	0.502	ND
Ck Flu R	2	0.281	0.252	2	ND
Ck6258	2	1.250	1.063	2	ND
C. auris	2	1.016	0.508	2	ND
C. parapsilosis	1.002	0.076	0.124	2	ND
A. fumigatus	2	0.515	0.484	ND	ND

Flu: fluconazole; Vori: voriconazole; Itra/itraconazole; Caspo: caspofungin; AB: amphotericin B.