Skip to main content
. Author manuscript; available in PMC: 2019 Sep 23.
Published in final edited form as: J Pathol. 2018 Mar 6;244(5):638–649. doi: 10.1002/path.5042

Table 1.

An overview of the chromatin regulator-associated genetic abnormalities in sarcomas

Sarcoma subtype Gene (protein) involved Associated genetic abnormality (% of cases) References
Synovial sarcoma (SS) SS18, SSX1/2/4 Chromosomal translocation forming SS18–SSX1/2/4 fusion
(~100%)		 [1,2,70]
Ewing sarcoma (ES) EWSR1, FLI1, ERG, ETV1, E1AF, FEV Chromosomal translocation forming EWS–FLI1/ERG/ETV1/E1AF/FEV fusion
(~100%)		 [3,87–90]
Malignant rhabdoid tumor (MRT)/atypical teratoid/rhabdoid tumor (AT/RT)/epithelioid sarcoma (EpS) SMARCB1 (BAF47) Homozygous loss
(98%, 98%, > 90%)		 [47,103–105]
Malignant peripheral nerve sheath tumors (MPNSTs) SUZ12, EED Heterozygous or homozygous loss
(70–92%)		 [128–130]