Table 2.
Gene enrichment
| Category | Dataset | OR | Upper CI (95%) | Lower CI (95%) | P | P corrected |
|---|---|---|---|---|---|---|
| Autism transcription | Dysregulated | 1.21 | 1.23 | 1.19 | 1.76E−15 | 2.81E−15 |
| Autism transcription | Downregulated | 1.87 | 1.94 | 1.8 | 2.00E−16 | 3.55E−16 |
| Autism transcription | Upregulated | 1.01 | 1.02 | 1 | 4.99E−01 | 4.99E−01 |
| Adult co-expression modules | Mod4 | 1.08 | 1.08 | 1.07 | 2.00E−16 | 3.55E−16 |
| Adult co-expression modules | Mod10 | 1.07 | 1.08 | 1.07 | 2.00E−16 | 3.55E−16 |
| Adult co-expression modules | Mod16 | 1.08 | 1.08 | 1.07 | 2.00E−16 | 3.55E−16 |
| Adult co-expression modules | Mod9 | 0.93 | 0.94 | 0.92 | 2.01E−14 | 2.92E−14 |
| Adult co-expression modules | Mod19 | 0.93 | 0.94 | 0.92 | 2.00E−16 | 3.55E−16 |
| Adult co-expression modules | Mod20 | 0.97 | 0.97 | 0.96 | 6.22E−05 | 7.66E−05 |
| Common variants | Common variants | 1 | 1.01 | 1 | 2.75E−01 | 2.93E−01 |
| Rare variants | Rare variants | 0.96 | 0.99 | 0.93 | 2.42E−01 | 2.76E−01 |
| Fetal co-expression modules | Moddev2 | 0.97 | 0.97 | 0.96 | 1.28E−11 | 1.70E−11 |
| Fetal co-expression modules | Moddev3 | 0.96 | 0.97 | 0.96 | 2.00E−16 | 3.55E−16 |
| Fetal co-expression modules | Moddev13 | 1.04 | 1.04 | 1.04 | 2.00E−16 | 3.55E−16 |
| Fetal co-expression modules | Moddev16 | 1.06 | 1.06 | 1.05 | 2.00E−16 | 3.55E−16 |
| Fetal co-expression modules | Moddev17 | 1.04 | 1.05 | 1.04 | 2.00E−16 | 3.55E−16 |
Odds ratio scores, confidence intervals and significance of all major classes of gene enrichment investigated in the discovery dataset