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. 2018 Aug 2;38(1):17–32. doi: 10.1038/s41388-018-0414-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — KDM8 is overexpressed in malignant prostate tissues and cancer cell lines. a Representative images of anti-KDM8 immunohistochemical (IHC) staining of prostate normal and malignant tissue sections. b Percentage of prostate cancer tumors with different Gleason scores that are scored as high or low (or negative) in the anti-KDM IHC analysis. c Western blot analysis of KDM8 in non-malignant RWPE1 cell line and cancerous prostate epithelial cell lines C4-2B, LNCaP, PC3, CWR22rv1, and DU145. GAPDH was used as a loading control. d KDM8 gene expression analysis in prostate cancer (TCGA dataset extracted from Oncomine database). Box plot derived from gene expression data in Oncomine database comparing the KDM8 expression in normal (n = 184) and in malignant cancer tissues (n = 141)