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. 2018 Aug 2;38(1):17–32. doi: 10.1038/s41388-018-0414-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Overexpression of KDM8 reprograms glucose metabolism in prostate cancer cells. a Heat map of metabolic gene expression in KDM8-overexpressed LNCaP cells (left panel) and the KDM8-overexpressed LNCaP cells knocking down with siRNA targeting PKM2 (right panel). The gene expression levels were measured by qRT-PCR. Data were analyzed as fold change as compared to the EV control (left panel) or si-NT after normalizing to internal control, 16S rRNA. b Measurements of the levels of extracellular lactate and c glucose update in EV control and KDM8-overexpressed LNCaP cells. Data are expressed as mean ± S.D. with three separate experiments. *p < 0.05. d A schematic diagram of glucose metabolic flux. Overexpression of KDM8 induces redirection of metabolic flux into the biomass synthesis pathways. The affected genes are marked in red (upregulated) or in blue (downregulated). The sizes of the circles are proportional to the expression levels of the genes indicated