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. 2019 Jan 30;38(21):4002–4014. doi: 10.1038/s41388-019-0680-2

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© The Authors 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Hierarchical clustering analysis of PDCs for expression of CAF and EMT associated-genes. a A list of 31 CAF associated-genes was used for clustering analysis of PDCs. The dendrogram showed the similarity of the non-tumorigenic PDCs and confirmed their CAF-like nature with upregulation of ACTA2, MYH9, and COL4A1. CM04-PDC does not show this CAF expression signature. b A dendrogram demonstrated an EMT signature for CM01, 02, 03, and 08-PDCs evidenced by upregulation of COL3A1, COL1A2, COL4A1, ITGB1, SPARC, ITGA5, VIM, and low expression of CDH1 and OCLN. CM04-PDC does not display this EMT signature