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. 2018 Feb 8;24(5):746–756. doi: 10.1038/s41380-017-0009-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 2 — Reversal of thalamic hyperactivity after antidepressant treatment. Repeated measures analysis of variance (rmANOVA) comparisons between fMRI-1 and fMRI-2 within healthy controls (HC), remitted depressed patients (rMD), and acute depressed patients (aMD). Acute patients were treated with escitalopram or venlafaxine for 12 weeks. a, F-test results depicts elevated activation of thalamic pulvinar nuclei in acute patients, which reversed to baseline values of HC after treatment. Activations represents difference in F-test between fMRI-2 vs. fMRI-1. b, Post-hoc t-tests revealed elevated activity in midcingulate cortex. Activations represents difference in t-test between fMRI-2 vs. fMRI-1. Errorbar-plots represent activation values of red circled-clusters, which survived family-wise error correction (FWE, cluster-level, p < 0.05). Left is left. Results are depicted at p < 0.001 uncorrected voxel level