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. 2019 Jan 14;38(18):3415–3427. doi: 10.1038/s41388-018-0652-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Allele-specific silencing of mutant p53 expression leads to cell death. Flow cytometric analysis of the sub-G1 DNA content (indicative of apoptosis) in cells were quantified 72 h post-transfection of the indicated siRNAs in the indicated cell lines, without (a) or with (b) CDDP treatment for 24 h. Representative histograms are shown from one experiment out of at least three independent repeats. % sub-G1 cells are indicated in the histogram (M1)