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. 2019 Mar 21;33(9):2306–2340. doi: 10.1038/s41375-019-0451-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Overview about all analyzed patients, their molecular information and breakpoint distribution. a Data from 109 patients which were analyzed with NGS in percentages. Their breakpoint distribution is displayed left (major BCR; n = 67) and right (minor BCR; n = 21). Five patients displayed only a reciprocal fusion, while 16 cases displayed no MLL rearrangement. b Top: chromosome 11 is depicted with highlighting of the MLL (red) and USP2 (green) genes. Below: all the genes between MLL and USP; blue marked genes: additional genes found in this study to be rearranged with MLL; orange marked genes: genes that have been earlier described to be rearranged with MLL. Recombinations between MLL and USP2 are caused by an inversion, with reciprocal alleles that carry additional deletions or complex rearrangements