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. 2018 Oct 24;33(5):1206–1218. doi: 10.1038/s41375-018-0292-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Sézary syndrome patients exhibit characteristically high levels of CD26⁻ cells and T_regs with increased TNFR2 expression. a Percentage of CD26⁻ cells from freshly isolated peripheral human CD4⁺ cells of Sézary syndrome patients and healthy controls (n = 1 Subjects E, H, I; n = 2 Subjects A, D, C; n = 3 Subjects B, FG, and n = 10 Controls). b Proportion of CD26^+/⁻ and CD7^+/⁻ lymphocytes. c. Proportion of lymphocyte populations (CD26⁻, T_reg, and T_eff) and TNFR2 expression of all patients except samples from subjects with tumor cells > 90% of CD4+ (Subjects E, I) and controls (n = 11 Patients, n = 11 Controls). d Individual histograms showing the massive amounts of TNFR2 expression on either tumor containing CD26⁻ cells or T_reg, cells in a characteristic Sezary syndrome subject (pink) compared to a control subject (blue). Data are mean ± SEM, underlined asterisks indicate significant difference between patient and controls determined by Z test (95% CI)