Fig. 5.

Genetic interaction between CCT complex and growth signaling pathways. a Adult wing images. ptc>+ is a control. Overexpression of PI3K^CA, Rheb, CycE, and yki-GFP resulted in increase in ptc-expressing tissue. Overexpression of Ras^V12 resulted in the embryonic lethality. Overexpression of EGFR^Act resulted in reduced wing size. PI3K^CA, Rheb, yki-GFP, ras^V12, or EGFP^Act overexpression was insufficient to rescue ptc>CCT4i phenotype. CycE overexpression partially rescued ptc>CCT4 RNAi phenotype. Scale bar, 400 μm. b Quantitative data on the size of the ptc-expressing domain shown in a. *P < 0.05, **P < 0.01. n = 3 (all genotypes). c Genetic interaction between CCT4 and insulin/TOR signaling components