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. 2019 Jul 8;38(34):6172–6183. doi: 10.1038/s41388-019-0872-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The structural alterations and amplification of the TERT gene in human cancer. a Schematic presentation of rearrangements and onco-viral insertation of the TERT locus. Left: The rearrangements occur most frequently in a 50 kb region proximal of the TERT gene, although the translocation to other chromsomes is also observed. The rearrangements are not random events, which often juxtapose the TERT coding sequence to strong enhancer elements. Right: Most integration breakpoints for onco-viral insertions are located in the TERT promoter region, and almost all the integrations contained at least one viral gene enhancer or promoter. b and c The structural variants and amplification of the TERT gene in a panel of human malignancies from the TCGA cohort analyses, respectively. GBM glioblastoma multiforme, SKCM skin cutaneous melanoma, BLCA bladder urothelial carcinoma, LIHC liver hepatocellular carcinoma, LGG brain lower-grade glioma, HNSC head and neck squamous cell carcinoma, THCA thyroid carcinoma, CESC cervical squamous cell carcinoma and endocervical adenocarcinoma, ACC adrenocortical carcinoma, PRAD prostate adenocarcinoma, LUSC lung squamous cell carcinoma, LUAD lung adenocarcinoma, PCPG Pheochromocytoma and paraganglioma, LUSC lung squamous cell carcinoma, TGCT testicular germ cell tumor, BRCA breast invasive carcinoma, STAD stomach adenocarcinoma, ESCA esophageal carcinoma, OV ovarian serous cystadenocarcinoma, DLBC lymphoid neoplasm diffuse large B cell lymphoma, KIRP kidney renal papillary cell carcinoma, KIRC kidney renal clear cell carcinoma, KICH kidney chromophobe, UVM uveal melanoma, SARC sarcoma, THYM thymus, CRC colorectal carcinoma, LAML acute myeloid leukemia, UCEC uterine corpus endometrial carcinoma, CHOL cholangiocarcinoma