Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 16;38(36):6382–6398. doi: 10.1038/s41388-019-0890-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — FOXO3 expression correlates with PERK levels in breast cancer patient samples. a Representative immunohistochemical staining images from two patient samples (high and low) showing correlations between FOXO3, PERK and P-eIF2a levels in a cohort of HER-2-positive breast cancer patient samples. b Staining results and Chi-square analysis. Chi-square statistical analysis was used to test the correlations between FOXO3, PERK and P-eIF2a expression in patients using SPSS 16.0. The correlation of FOXO3 and PERK expression with clinical parameters (lower panel). In statistical analysis, *P < 0.05, **P < 0.01, ***P < 0.001 were considered as significant. c, d Correlation analysis using Gene Expression Profiling Interactive Analysis (GEPIA) [28]. The results indicated that a strong and positive correlation between FOXO3 and PERK mRNA expression in 1085 breast cancer cases and 291 normal breast tissue samples derived from The Cancer Genome Atlas (TCGA) database, respectively. ****P < 0.0001