Table 1.
Clinical and biological characteristics
| Variable | ALL | DA-EPOCH-R | R-CHOP | SMD before/after |
|---|---|---|---|---|
| N = 114 | N = 51 | N = 63 | ||
| Age | ||||
| Median | 62 years | 58 years | 65 years | 0.296/<0.001 |
| Range | 29–81 | 29–79 | 36–81 | |
| Age > 65 years | 43 (38%) | 14 (27%) | 29 (46%) | |
| Sex | ||||
| Male | 70 (62%) | 32 (63%) | 38 (60%) | 0.049/0.018 |
| Female | 44 (38%) | 19 (37%) | 25 (40%) | |
| Histology | ||||
| DLBCL | 106 (93%) | 47(92%) | 59 (94%) | |
| Transformed | 8 (7%) | 4 (8%) | 4 (6%) | — |
| Stage | ||||
| I–II | 28 (25%) | 8 (16%) | 20 (32%) | 0.850/0.079 |
| III–IV | 86 (75%) | 43 (84%) | 43 (68%) | |
| IPI | ||||
| 1–2 | 62 (54%) | 24 (47%) | 38 (60%) | 0.332/0.101 |
| 3–5 | 52 (46%) | 27 (53%) | 25 (40%) | |
| BM involvement | ||||
| Yes | 22 (19%) | 16 (32%) | 6 (10%) | 0.552/0.421 |
| No | 92 (81%) | 35 (68%) | 57 (90%) | |
| Extranodal involvementa | ||||
| Yes | 69 (60%) | 46 (90%) | 23 (36%) | — |
| No | 45 (40%) | 5 (10%) | 40 (64%) | |
| CNS involvement | ||||
| Leptomeningeal | 3 (3%) | 2 (4%) | 1 (1%) | — |
| Cytogenetic abnormalities | ||||
| DE-only | 58 (51%) | 18 (35%) | 40 (63%) | 0.749/0.119 |
| DE with SH | 29 (25%) | 16 (31%) | 13 (21%) | |
| DE with DH/TH | 10 (9%) | 8 (16%) | 2 (3%) | |
| DE with atypical DH | 15 (13%) | 9 (18%) | 6 (10%) | |
| Missing | 2 (2%) | 0 (0%) | 2 (3%) | |
| FISH rearrangements | ||||
| MYC R | 7 (6%) | 5 (10%) | — | |
| BCL2 R | 8 (7%) | 5 (10%) | 2 (3%) | |
| BCL6 R | 14 (12%) | 6 (12%) | 3 (5%) | |
| MYC R/BCL2 R | 5 (4%) | 4 (7%) | 8 (13%) | |
| MYC R/BCL6 R | 2 (2%) | 2 (4%) | 1 (2%) | |
| MYC R/BCL2 R/BCL6 R | 3 (3%) | 2 (4%) | 0 (0%) | |
| Cell of origin (Hans) | 0.334/0.049 | |||
| GCB | 42 (37%) | 22 (43%) | 20 (31%) | |
| Non GCB | 57 (50%) | 25 (49%) | 32 (51%) | |
| Not evaluable | 15 (13%) | 4 (8%) | 11 (18%) | |
SMD Standardized mean difference calculated before and after weighting, DLBCL diffuse large B-cell lymphomas, BM bone marrow, FISH fluorescence in situ hybridization, DE double expressor, SH single-hit, DH double hit, TH triple hit, R rearrangements, GCB germinal center B-cell lymphomas
aAt least one extranodal involvement