Table 2.

Studies suggesting that MSCs affect hematologic malignancy by decreasing or increasing tumor growth in vivo

Isolated MSC	Tumor cell	Tumor cell no. (cells)	Animal type	Findings	Proposed mechanism	Reference
Mouse BM-MSC	B-lymphoma (A20)	1 × 104	BALB/c mouse	Inhibit lymphoma cell growth	Inhibition of IL-10 secretion to immune evasion of lymphoma cells	Song et al. [22]
Human BM-MSC	Lymphoma (BJAB and SKW6.4)	2 × 106	SCID mouse	Inhibit lymphoma cell growth	Induction of apoptosis of endothelial cells to form new blood vessels	Secchiero et al. [77]
Human AT-MSC	CML (K562)	2 × 105	BALB/c-nu mouse	Inhibit leukemic cell proliferation	Induction of cell cycle arrest by secretion of DKK-1	Zhu et al. [74]
Human BM-MSC	CML (BV173)	1 × 106	NOD/SCID mouse	Induce leukemic cell growth and reduce apoptosis	Formation of a cancer stem cell niche to preserve the self-renewal ability of leukemic cells	Ramasamy et al. [23]
Human AT-MSC	ALL (Reh, CCRF-CEM, SUP-T1, and CCRF-HSB2)	1 × 105 1 × 107	NOD/SCID mouse	Induce leukemic cell growth	—	Lee et al. [110]

MSC mesenchymal stem cell, BM bone marrow, CML chronic myeloid leukemia, ALL acute lymphoblastic leukemia, IL interleukin, AT adipose tissue