Table 3.
The significantly altered pathways in major depressive disorder with children and adolescents and adults
| Children and adolescents MDD | Adults MDD | ||
|---|---|---|---|
| Pathways | p-value | Pathways | p-value |
| IPA analyses | |||
| Adenine and Adenosine Salvage III | 6.56E-07 | tRNA Charging | 2.80E-04 |
| Purine Ribonucleosides Degradation to Ribose-1-phosphate | 1.10E-06 | FXR/RXR Activation | 7.80E-04 |
| Adenosine Nucleotides Degradation II | 3.14E-06 | S-adenosyl-L-methionine Biosynthesis | 2.52E-03 |
| Purine Nucleotides Degradation II (Aerobic) | 7.40E-06 | Methionine Salvage II (Mammalian) | 2.84E-03 |
| Glycine Degradation (Creatine Biosynthesis) | 3.69E-05 | Lipoate Biosynthesis and Incorporation II | 3.15E-03 |
| MetaboAnalyst analyses | |||
| Fatty acid biosynthesis | 9.03E-5 | Glycerophospholipid metabolism | 7.83E-4 |
| Arginine and proline metabolism | 3.93E-02 | ||
IPA ingenuity pathway analysis, MDD major depressive disorder