Fig. 3.

Knockdown of USP39 decreases proliferation, invasion, and migration of glioma cells in vivo. a Representative images of luciferase bioluminescence at the indicated days after injection of luciferase-expressing U87MG and P3 cells into the brains of nude mice. b Graphic representation of the total flux at the indicated days for the indicated cell types. c Representative images of HE staining of orthotopic xenografts derived from the indicated cell types, U87MG- and P3-sh-USP39-1 cells and controls. Scale bars, 1000 and 200 µm. d Kaplan–Meier analysis of survival for tumor bearing mice implanted with U87MG- and P3-sh-USP39-1 cells and controls. Student’s t-test: n.s. = not significant, *p < 0.05, **p < 0.01, ***p < 0.001. Log-rank test: p < 0.01