Table 3.
Cell surface proteins overexpressed in cancer cells
| Preferentially overexpressed in HPV+ HNSCC | |||||||
|---|---|---|---|---|---|---|---|
| genes | mean of expression controls | mean of expression HPV+ | fold change HPV+/controls | FDR | mean of expression HPV- | fold change HPV-/controls | FDR |
| ITGAM | 70.80 | 370.67 | 5.24 | 5.24E-04 | 19.24 | 0.27 | 5.11E-01 |
| VCAM1 | 169.55 | 4133.39 | 24.38 | 8.23E-24 | 0.00 | 0.00 | 2.79E-01 |
| TMEM26 | 5.16 | 27.92 | 5.41 | 2.20E-06 | 4.67 | 0.91 | 9.34E-01 |
| NTN3 | 1.55 | 10.54 | 6.81 | 2.27E-13 | 1.87 | 1.21 | 6.75E-01 |
| PDCD1LG2 | 63.14 | 259.03 | 4.10 | 3.89E-06 | 58.76 | 0.93 | 7.18E-01 |
| PON1 | 0.90 | 3.23 | 3.57 | 1.15E-03 | 0.66 | 0.73 | 7.24E-01 |
| ADAM22 | 8.12 | 58.64 | 7.22 | 1.39E-09 | 12.89 | 1.59 | 4.23E-01 |
| SLC12A5 | 1.51 | 9.51 | 6.29 | 7.36E-14 | 2.59 | 1.72 | 8.83E-02 |
| CRB2 | 20.66 | 187.34 | 9.07 | 7.13E-18 | 6.69 | 0.32 | 9.55E-02 |
| ITGA2B | 8.70 | 50.16 | 5.77 | 5.06E-24 | 17.67 | 2.03 | 4.56E-05 |
| OLFM1 | 267.08 | 2961.37 | 11.09 | 1.02E-13 | 758.81 | 2.84 | 9.61E-03 |
| ZP4 | 0.58 | 3.40 | 5.82 | 1.61E-04 | 1.65 | 2.82 | 9.25E-02 |
| CELSR3 | 118.58 | 737.21 | 6.22 | 2.82E-37 | 304.07 | 2.56 | 3.04E-10 |
| ROR2 | 94.70 | 522.15 | 5.51 | 1.54E-08 | 289.49 | 3.06 | 6.37E-04 |
| CLEC1A | 22.28 | 124.37 | 5.58 | 3.69E-05 | 72.79 | 3.27 | 1.98E-02 |
| ICAM1 | 578.30 | 3194.41 | 5.52 | 1.09E-02 | 1384.93 | 2.39 | 4.35E-01 |
| PTGIR | 15.28 | 86.87 | 5.68 | 5.89E-07 | 13.63 | 0.89 | 9.18E-01 |
| Preferentially overexpressed in HPV- HNSCC | |||||||
|---|---|---|---|---|---|---|---|
| genes | mean of expression controls | mean of expression HPV- | fold change HPV-/controls | FDR | mean of expression HPV+ | fold change HPV+/controls | FDR |
| ALPP | 0.61 | 31.28 | 51.34 | 2.41E-125 | 0.00 | 0.00 | 9.22E-01 |
| NT5E | 213.94 | 1257.01 | 5.88 | 1.75E-04 | 387.26 | 1.81 | 5.03E-01 |
| SGCZ | 0.26 | 2.10 | 8.13 | 2.25E-02 | 0.20 | 0.76 | 9.76E-01 |
| IL13RA2 | 21.29 | 94.73 | 4.45 | 4.85E-06 | 21.58 | 1.01 | 1.00E+00 |
| ODZ1 | 0.22 | 56.86 | 254.91 | 4.79E-06 | 0.00 | 0.00 | 1.00E+00 |
| PTPRD | 77.15 | 283.72 | 3.68 | 1.10E-04 | 40.38 | 0.52 | 4.50E-01 |
| BCHE | 27.30 | 111.63 | 4.09 | 8.96E-04 | 3.02 | 0.11 | 3.10E-01 |
| ORM1 | 0.58 | 8.63 | 14.95 | 8.47E-06 | 0.00 | 0.00 | 7.47E-01 |
| NTSR1 | 9.37 | 62.44 | 6.67 | 1.10E-39 | 1.78 | 0.19 | 3.80E-04 |
| FBN2 | 212.38 | 1626.51 | 7.66 | 5.89E-15 | 426.47 | 2.01 | 1.80E-02 |
| FGFR4 | 46.56 | 200.06 | 4.30 | 2.94E-05 | 107.51 | 2.31 | 5.09E-02 |
| HTR1D | 2.40 | 29.31 | 12.22 | 5.25E-14 | 3.83 | 1.60 | 3.79E-01 |
| TFPI2 | 38.36 | 357.56 | 9.32 | 9.91E-13 | 0.00 | 0.00 | 1.54E-01 |
| MDGA1 | 141.13 | 490.76 | 3.48 | 7.56E-07 | 143.25 | 1.02 | 1.00E+00 |
| NXF2 | 13.20 | 67.24 | 5.09 | 1.12E-10 | 0.00 | 0.00 | 1.48E-02 |
| MMP13 | 159.86 | 4039.67 | 25.27 | 7.03E-46 | 322.68 | 2.02 | 6.61E-02 |
| PCDHGB1 | 33.00 | 121.46 | 3.68 | 5.06E-10 | 13.96 | 0.42 | 2.58E-02 |
| PROCR | 175.03 | 899.66 | 5.14 | 2.08E-08 | 440.34 | 2.52 | 3.15E-03 |
| F2 | 0.30 | 5.53 | 18.65 | 9.83E-47 | 0.00 | 0.00 | 1.33E-01 |
| CDH4 | 5.15 | 41.35 | 8.03 | 1.53E-04 | 0.00 | 0.00 | 5.65E-01 |
| ITIH2 | 0.21 | 1.22 | 5.91 | 4.05E-04 | 0.00 | 0.00 | 4.65E-01 |
| TSPAN18 | 265.29 | 872.08 | 3.29 | 2.50E-03 | 272.16 | 1.03 | 1.00E+00 |
| PTGS2 | 256.78 | 2080.61 | 8.10 | 4.12E-06 | 1050.23 | 4.09 | 1.41E-02 |
| CLEC12A | 0.56 | 33.17 | 59.74 | 6.14E-05 | 2.11 | 3.81 | 8.65E-01 |
| CD70 | 2.98 | 90.85 | 30.52 | 1.32E-07 | 50.91 | 17.11 | 5.52E-03 |
| SDK1 | 145.67 | 1152.86 | 7.91 | 2.50E-03 | 619.05 | 4.25 | 1.36E-01 |
| ABCC2 | 13.09 | 59.09 | 4.51 | 4.73E-04 | 1.75 | 0.13 | 3.59E-01 |
| Overexpressed in both HPV+ and HPV- HNSCC | |||||||
|---|---|---|---|---|---|---|---|
| genes | mean of expression controls | mean of expression HPV+ | fold change HPV+/controls | FDR | mean of expression HPV- | fold change HPV-/controls | FDR |
| CHST7 | 60.94 | 213.32 | 3.50 | 4.01E-09 | 289.09 | 4.74 | 2.77E-11 |
| TMEM200B | 55.56 | 177.05 | 3.19 | 5.43E-06 | 184.94 | 3.33 | 2.78E-06 |
| NXPH4 | 271.45 | 910.32 | 3.35 | 3.39E-03 | 878.77 | 3.24 | 4.89E-03 |
| COL11A1 | 32.91 | 282.92 | 8.60 | 3.56E-02 | 235.69 | 7.16 | 7.99E-02 |
| MGAT5B | 5.92 | 44.42 | 7.50 | 5.46E-07 | 35.85 | 6.05 | 2.23E-05 |
| LY6K | 434.86 | 1471.16 | 3.38 | 1.27E-14 | 1458.68 | 3.35 | 1.24E-11 |
| ICAM5 | 20.12 | 109.12 | 5.42 | 2.65E-16 | 101.61 | 5.05 | 1.14E-11 |
| EPHB2 | 132.77 | 537.62 | 4.05 | 7.53E-05 | 594.52 | 4.48 | 1.64E-05 |
| PLAU | 805.67 | 3685.90 | 4.57 | 2.04E-07 | 5178.89 | 6.43 | 7.24E-10 |