Fig. 7.

Clinical relevance of MYEOV with expression levels of TGFBR2 and USP15 and activation of TGF-β signaling. a Expression of MYEOV is associated with TGFBR2 and USP15 expression levels and localization of SMAD3 in clinical NSCLC specimens. Two representative cases (high and low MYEOV) are shown. b Percentage of specimens showing high- or low- MYEOV expression in relation to the expression levels of TGFBR2, USP15 and nuclear or cytoplasmic SMAD3. The χ²-test was used to analyze statistical significance. *P < 0.05. c GSEA plot showing MYEOV expression in relation to metastasis-associated gene signature and TGF-β-activated gene signature in the TCGA lung cancer dataset