Figure 3.

Comparison of experimental permeability data for natural and artificial membrane systems. (A) Correlation between intrinsic permeability coefficients obtained in situ rodent brain perfusion experiments $\left(\text{log}{P}_{0\text{exp }}^{\text{BBB}}\right)$ vs Caco-2/MDCK assays $\left(\text{log}{P}_{0\exp }^{\text{Caco}-2/\text{MDCK}}\right)$. (B) Correlation between intrinsic BBB or Caco-2/MDCK permeability coefficients vs intrinsic permeability coefficients through BLM/liposomes $\left(\text{log}{P}_{0\text{exp }}^{\text{BLM}}\right)$. Colors indicate different types of molecules: red for acids, blue for bases, gray for neutral molecules, and yellow for zwitterions. The number of molecules “n” is indicated in parentheses. Experimental BLM, BBB, and Caco-2/MDCK permeability coefficients are from Tables S7 and S8.