Figure 4.

Experimental and calculated permeability data for PAMPA-DS. (A) Correlation between intrinsic permeability coefficients obtained in PAMPA-DS assays and using BLM or liposomes $\left(\text{log}{P}_{0\exp }^{\text{BLM}}\right)$. Experimental PAMPA-DS and BLM data were taken from Table S9. (B) Correlation between permeability coefficients through the plasma membrane and PAMPA-DS. Intrinsic permeability coefficients of molecules through the plasma membrane $\left(\text{log}{P}_{0\text{calc }}^{\text{PM}}\right)$ were calculated using eq 17. Experimental data for PAMPA-DS $\left(\text{log}{P}_{0\text{calc }}^{\text{PAMPA-DS }}\right)$ were taken from Table S5. Colors indicate different types of molecules: red for acids, blue for bases, gray for neutral molecules, and yellow for zwitterions. The number of molecules “n” is indicated in parentheses.