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. Author manuscript; available in PMC: 2020 Sep 24.
Published in final edited form as: J Am Coll Cardiol. 2019 Sep 24;74(12):1543–1553. doi: 10.1016/j.jacc.2019.06.077

Figure 3. Sex-specific multivariable-adjusted associations of single biomarkers with outcomes.

Figure 3.

Association of biomarkers with CVD outcomes is modified by sex. Biomarkers presented here show sex*biomarker interaction P<0.05. All biomarkers are rank normalized. Original assay units are pg/mL. Abbreviations: HR = hazard ratio Central Illustration. Age-adjusted and multivariable-adjusted associations of single biomarkers with sex. Waterfall plot displays ß regression coefficients for individual biomarkers. ß-coefficients represent difference in biomarker concentration between women and men (referent), units expressed in standard deviations of rank-normalized biomarker. Positive ß-coefficient represents higher concentration in women and negative ß-coefficient represents higher biomarker concentration in men. Red bars represent age-adjusted model, blue bars represent multivariable-adjusted model. Multivariable model adjusts for age, sex, SBP, HTN treatment, HDL, total cholesterol, BMI, DM, and smoking. Abbreviations: MV = multivariable.