Table 2.
Top 20 protein biomarkers with greatest observed differences between women vs men
| Biomarker | ß-coefficient | SE | p-value |
|---|---|---|---|
| Higher in women | |||
| Leptin | 1.052 | 0.018 | <1.00E-500 |
| Ceruloplasmin | 0.908 | 0.023 | 1.02E-294 |
| Hemopexin | 0.579 | 0.024 | 3.23E-120 |
| BNP | 0.470 | 0.022 | 1.67E-94 |
| CNTN1 | 0.455 | 0.025 | 4.04E-72 |
| IGF1 | 0.451 | 0.024 | 2.84E-77 |
| KLKB1 | 0.443 | 0.025 | 5.94E-68 |
| IGFBP1 | 0.413 | 0.022 | 9.45E-79 |
| EFEMP1 | 0.409 | 0.022 | 6.34E-74 |
| C2 | 0.389 | 0.025 | 5.68E-52 |
| Higher in men | |||
| CD56 | −0.839 | 0.024 | 5.03E-254 |
| Myoglobin | −0.803 | 0.023 | 2.00E-252 |
| GMP140 | −0.338 | 0.025 | 4.72E-39 |
| sGP130 | −0.278 | 0.025 | 3.73E-27 |
| BCHE | −0.274 | 0.025 | 2.31E-27 |
| MMP8 | −0.254 | 0.025 | 7.72E-23 |
| OSTEO | −0.245 | 0.026 | 1.01E-20 |
| A1M | −0.215 | 0.025 | 1.47E-17 |
| IGFBP2 | −0.188 | 0.023 | 1.03E-15 |
| REGIA | −0.187 | 0.025 | 3.52E-13 |
For full list of 71 proteins, please refer to Supplemental Table 1.
All biomarkers are rank normalized. Original assay units are pg/mL.
*
ß-coefficient: For women compared to men, 1 standard deviation increase in rank normalized biomarker.
+ ß-coefficient: higher in women
−ß-coefficient: higher in men
MV model adjusts for age, sex, SBP, HTN treatment, HDL, total cholesterol, BMI, DM, and smoking