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. Author manuscript; available in PMC: 2020 Sep 19.
Published in final edited form as: Mol Cell. 2019 Sep 19;75(6):1092–1101. doi: 10.1016/j.molcel.2019.08.026

Figure 4. Technologies developed to reveal KMT substrates.

Figure 4.

(A) Typical mass spectrometry (MS)-based proteomics pipeline for the identification of lysine methylation sites from cultured cells. (B) SPOT arrays evaluate the sequence tolerance of known KMT peptide substrates. (C) Protein arrays facilitate de novo identification of KMT substrates. (D) Lysine-oriented peptide libraries (K-OPL) reveal the sequence determinants of KMT substrate selectivity.