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. 2019 Jan 30;38(22):4250–4263. doi: 10.1038/s41388-019-0702-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The role of NOXO1 in TNF-α-induced ROS production. a Representative photographs of DHE staining (top) and merged images with DAPI staining (bottom) of wild-type mouse stomach (left), K19-C2mE mouse gastritis-associated hyperplasia (center), and Gan mouse gastric tumors (right). Dashed lines indicate the neck region of K19-C2mE hyperplasia. Scale bars, 250 µm. b Representative photographs of DHE staining (top) and merged images with DAPI (bottom) of SNU601 cells at the indicated time after TNF-α stimulation. Scale bars, 100 µm. c The mean ratio of the SNU601 cells positively stained for DHE at the indicated time after TNF-α stimulation (mean ± s.d.). **p < 0.01; N.S. not significant. d The relative mRNA levels of NOXO1 in the sh-NOXO1 lentivirus-infected cells compared to the control SNU601 cells are shown. **p < 0.01. e Representative photographs of DHE staining (top) and merged images with DAPI (bottom) of TNF-α-stimulated sh-NOXO1 lentivirus-infected (right) and TNF-α-stimulated control lentivirus-infected SNU601 cells (left). Scale bars, 100 µm. f The mean ratio of the TNF-α-stimulated sh-NOXO1 and control lentivirus-infected cells positively stained for DHE (mean ± s.d.). *p < 0.05