Fig. 6.

IL-4Rα is not involved in Stat6 activation during DNA damage a–j. a, b p-H2AX index in AOM-treated (4 h) Il-4rα^flox (n = 5) and Il-4rα^ΔIEC mice (n = 6); a, c Index of cleaved CASPASE 3 expressing IEC in unchallenged (d0) and AOM-treated (8 h) Il-4rα^flox and Il-4rα^ΔIEC mice (Il-4rα^flox d0 n = 3; Il-4rα^ΔIEC d0 n = 5; Il-4rα^flox + 8 h AOM n = 4; Il-4rα^ΔIEC + 8 h AOM n = 4); d–j CAC model performed with Il-4rα^flox and Il-4rα^ΔIEC mice (n = 10/genotype); d Representative H&E stained sections of colonic tumors from Il-4rα^flox and Il-4rα^ΔIEC mice; e, f Tumor incidence and tumor size of Il-4rα^flox and Il-4rα^ΔIEC mice at the end of the CAC model (n = 10/genotype); g, h BrdU incorporation in tumors from Il-4rα^flox (n = 5) and Il-4rα^ΔIEC (n = 7) mice; i, j Immunohistochemical staining and index of p-STAT3 Y705 expressing tumor epithelia in Il-4rα^flox and Il-4rα^ΔIEC mice (n = 3/genotype). Data are mean ± SEM