Fig. 7.

Stat6 promotes sporadic inflammation-independent carcinogenesis a–h. a Colitis-independent carcinogenesis (sporadic) model performed with WT and Stat6^−/− mice; b Representative H&E stained sections of colons from WT and Stat6^−/− mice 20 weeks after the first AOM injection; c, d Tumor incidence and tumor size in WT and Stat6^−/− mice (WT n = 9; Stat6^−/− n = 11); e, f Immunohistochemical staining and index of p-STAT3 Y705 expressing tumor epithelia in WT and Stat6^−/− mice (WT n = 5; Stat6^−/− n = 3); g BrdU incorporation in tumors from WT and Stat6^−/− mice (WT n = 4; Stat6^−/− n = 3); h Index of p-H2AX expressing tumor epithelia in WT (n = 5) and Stat6^−/− mice (n = 3)