. 2019 Oct;47(10):1122–1135. doi: 10.1124/dmd.119.086744

TABLE 2.

Comparison of brain distribution of MEK inhibitors in wild-type mice (data are presented as means)

MEK Inhibitor	Dose mg/kg	K_p	K_p,uu	Reference
Trametinib	5 (i.v.)	0.15	0.15	Vaidhyanathan et al. (2014)
Trametinib	5 (i.v.)	0.15	0.15	Gampa et al. (2018)
Cobimetinib^a	10 (p.o.)	0.32	0.027	Choo et al. (2014)
E6201	40 (i.v.)	2.66	0.14	Gampa et al. (2018)

MEK, mitogen-activated protein kinase enzyme; K_p (AUC ratio), the ratio of AUC_(0-t,brain) to AUC_(0-t,plasma) using total drug concentrations; K_p,uu (AUC ratio), the ratio of AUC_(0-t,brain) to AUC_(0-t,plasma) using free drug concentrations.

^{^a}

K_p and K_p,uu based on plasma and brain concentrations 6 hours postdose.