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. 2019 Oct;47(10):1195–1205. doi: 10.1124/dmd.119.086348

Fig. 5.

Fig. 5.

Stereoselectivity of efavirenz metabolism. Shown is formation of 8-hydroxyefavirenz from S-efavirenz (●) and R-efavirenz (▲) by CYP2B6.1. The solid line represents predicted concentrations on the basis of parameters from nonlinear regression using the Hill equation for 8-hydroxylation of S-efavirenz and R-efavirenz. The inset compares predicted concentrations for R-efavirenz hydroxylation on the basis of parameters from nonlinear regression using the Hill equation (solid line) and Michaelis-Menten equation (dotted line).