TABLE 2.

8-Hydroxyefavirenz and 8,14-dihydroxyefavirenz formation in low substrate concentration range

S-Efavirenz	8-Hydroxyefavirenz	8,14-diOH-efavirenz
µM	pmol/min per picomoles	pmol/min per picomoles	%	%
0.25	0	0.014 ± 0.010	0	100
0.5	0.001 ± 0.001	0.055 ± 0.046	2	98
1.25	0.055 ± 0.009	0.209 ± 0.033	21	79
2.5	0.332 ± 0.048	0.460 ± 0.182	42	58
5.0	1.46 ± 0.29	0.405 ± 0.078	78	22
10	2.43 ± 0.10	0.505 ± 0.144	83	17
20	4.03 ± 0.28	0.201 ± 0.095	95	5