TABLE 5.

Summary of reported 8-hydroxylation of S-efavirenz

Relative activities are shown as percentage of CYP2B6 variants Cl_int (Cl_max for this study) compared with the wild type, on the basis of data in Table 3.

	Bumpus et al., 2006	Ariyoshi et al., 2011	Zhang et al., 2011	Xu et al., 2012	Radloff et al., 2013	Watanabe et al., 2018	This Study (Clmax)
Expression system	E. coli	Sf9	E. coli	SF9	COS-1	HEK	T. ni
CYP2B6.1	100	100	100	100	100	100	100
CYP2B6.4	170	142	96			122	144
CYP2B6.5			138		83	109	92
CYP2B6.6		50	20	49	183	266	56
CYP2B6.7			156			166	59
CYP2B6.9			33			172	48
CYP2B6.17						85	89
CYP2B6.19						37	48
CYP2B6.26						183	56