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. 2019 Sep 20;9(9):e029420. doi: 10.1136/bmjopen-2019-029420

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Derivation of the study population and five cohorts included in this study. Cohorts 1–4 were invited for HC in the years beginning 1 April 2011, 2012, 2013 and 2014, respectively, while cohort 5, which was the control group, was not invited. DOB, date of birth; GP, general practice; HC, Health Checks.