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. 2019 Sep 17;12:2933–2942. doi: 10.2147/IDR.S211721

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© 2019 Banerjee et al.

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Anti-leishmanial activity of Spergulin-A. (A) Structure of the triterpenoid saponins Spergulin-A. (B) Dose-dependent effects of Spergulin-A against acellular stages, namely the promastigotes and axenic amastigote of Leishmania donovani after 24, 48 and 72 hrs interval. (C) Dose-dependent effect of Spergulin-A against the intracellular amastigote of L. donovani after 24 hrs of treatment and expressed as number of parasites/20 MФs. (D) 24 hrs time lapse evaluation of anti amastigote effect of Spergulin-A at 30 μg/mL for 72 hrs. (E) Miltefosine LC₅₀ and LC₉₀ values against promastigote, axenic amastigote and intracellular amastigote forms of L. donovani at 24, 48 and 72 hrs time lapse. All values are expressed as mean ± SEM from triplicate assays from three independent experiments (P-values ≤0.05 (*) or ≤0.01 (**) vs control). ^#Statistical significance of treated macrophages with different time lapses with respect to 0 hrs. ^¥Statistical significance of the differences between the infected macrophages and treated macrophages at the same time.