Table 1.

Summary of variables and planned assays

Clinical variables	Disease quantitation variables	Established markers	Unbiased omics approaches	Candidate approaches
Demographics Standard modifiable cardiovascular risk factors (SMuRFs) Hypertension Hyperlipidaemia Diabetes Smoking Other medical history: BMI Family history of IHD Current medications History of cardiac symptoms	Coronary Artery Calcium Scores Gensini score Modified Gensini score (see figure 2) Frontier System semiautomated plaque analysis (syngo.via, Siemens Healthcare, Erlangen)	Cardiac Troponin NT-proBNP Inflammatory CRP VCAM-1 ICAM-1 IL-6	Metabolomics Proteomics Lipidomics Transcriptomics Genomics Immunophenotyping	Redox signalling dysregulation Endothelial cell signalling dysregulation Soluble factors released by inflammatory plaque Apoptosis signalling Mitochondrial function Angiogenesis potential Disorders of overall coagulation Soluble platelet factors Alpha-gal antibodies Heavy metal toxicities Galectin-3

BMI, body mass index; CRP, C reactive protein; ICAM-1, intercellular adhesion molecule 1; IHD, ischaemic heart disease; IL-6, interleukin-6; NT-proBNP, N-terminal-proB-type natiuretic peptide; VCAM-1, vascular cell adhesion molecule 1.