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. 2019 Sep 17;12:7623–7636. doi: 10.2147/OTT.S208275

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© 2019 Lu et al.

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mircoRNA-target hubgenes network analysis by cytoscape. (A) The hubgenes of downregulated miRNAs group included CDC27, CDC23, RNF213, SMURF1, SMURF2, UBE4A, LMO7, WSB1 which were regulated by miR-424, KLHL2 and RNF6 were regulated by miR-181a-5p. (B) The hubgenes of upregulated miRNAs group included MYLIP, SOCS3 which were regulated by miR-455-5p, FBXW4, TRIM71, STAT3, UBE2R2, UBE2G1 which were regulated by miR-125b-2-star, ASB13, BCL2L1 which were regulated by miR-491-5p and KBTBD8, which were regulated by miR-99a-5p.